• Analysis of Bottlenecks in Experimental Models of Infection 

      Abel, Sören; Schulz Zur Wiesch, Pia; Davis, Brigid M.; Waldor, Matthew K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-11)
    • Deciphering the landscape of host barriers to Listeria monocytogenes infection 

      Zhang, Ting; Abel, Sören; Abel zur Wiesch, Pia; Sasabe, Jumpei; Davis, Brigid M.; Higgins, Darren E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-30)
      <i>Listeria monocytogenes</i> is a common food-borne pathogen that can disseminate from the intestine and infect multiple organs. Here, we used sequence tag-based analysis of microbial populations (STAMP) to investigate <i>L. monocytogenes</i> population dynamics during infection. We created a genetically barcoded library of murinized <i>L. monocytogenes</i> and then used deep sequencing to track ...
    • Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization 

      Warr, Alyson R; Hubbard, Troy P; Munera, Diana; Blondel, Carlos J; Abel zur Wiesch, Pia; Abel, Sören; Wang, Xiaoxue; Davis, Brigid M.; Waldor, Matthew K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-12)
      Enterohemorrhagic <i>Escherichia coli</i> O157:H7 (EHEC) is an important food-borne pathogen that colonizes the colon. Transposon-insertion sequencing (TIS) was used to identify genes required for EHEC and <i>E. coli</i> K-12 growth <i>in vitro</i> and for EHEC growth <i>in vivo</i> in the infant rabbit colon. Surprisingly, many conserved loci contribute to EHEC’s but not to K-12’s growth <i>in ...